THE EFFECT OF DOPAMINE ON SERUM LACTATE LEVEL IN OPEN HEART SURGERY IN PATIENTS WITH EF ≤35%
Keywords:Dopamine, Serum lactate level, Cardiac surgery.
AbstractObjective: To evaluate the efficacy of dopamine on hyperlactatemia in patient's
candidate for elective open heart surgery with EF≤35%.
Methodology: In this randomized double blind clinical trial we evaluated 101
patients age between 18-75 candidate for elective open heart surgery with
EF≤35% undergone CPB in Rajaie Cardiovascular center. Patients were
randomized and allocated in to two groups. One group received normal saline (NS
or group A, 51 patients) and the other received low dose of dopamine
(2μgr/kg/min) (dopamine or B group 50 patients).
Results: Patients in the study population had more diabetes mellitus (29% vs
16%, p< 0.001), hypertension (61% vs 51%, p <0.001), hypercholesterolemia
(66% vs 54%, p <0.001), and family history of coronary artery disease (57% vs
50%, p < 0.01) Of the study population (29%) had a history of diabetes mellitus.
PMI occurred in 5% of the study population. PMI occurred in five patients, 1 with
3 stents, 2 with 2 stents and 1 with 3 stents.
Conclusion: Low dose of dopamine did not affect the lactate serum levels in
patients with EF≤35% undergoing open heart surgery.