OBESITY IN CHRONIC HEART FAILURE IS ASSOCIATED WITH REDUCED EXERCISE HYPERPNEIC RESPONSE
Keywords:Obesity, Heart failure, Exercise
AbstractObjective: Patients with chronic heart failure manifest an inappropriate elevation
in their ventilatory response to treadmill exercise. Increased body mass index
may restrict the ventilatory response to exercise, but the relationship between
obesity and ventilatory response in chronic heart failure(CHF) has not been well
Methodology: We analysed data from 246 consecutive patients with chronic
heart failure, who underwent cardiopulmonary exercise testing.
Exercise testing was performed on a treadmill according to the modified Bruce
protocol, with continuous on-line respiratory gas. The slope of the relationship
between ventilation (VE) and CO2 production (VCO ) was determined by 2
computerised graphical analysis (VE/VCO slope). 2
Results: Patients were aged 60±10.7 years (mean±SD), and had mean left
ventricular ejection fraction 27.7±13.9%, peak oxygen uptake 17.2±6.2
ml/min/kg. The subjects had mean body mass index (BMI) of 26.6±4.3 kg/m2
(mean±SD), and VE/VCO slope values of 37.3±10.2. The correlation between 2
BMI and VE/VCO slope was highly significant and inverse -0.455 (p<0.0001). 2
When the patients were divided into categories according to BMI (<22, 22-30,
>30), there were differences between the mean VE/VCO slopes of each group, 2
which was significant for each pair of comparisons.
Conclusion: This study suggests that patients with normal or mildly increased
BMI show a relatively greater hyperpneic response to exercise. In contrast,
patients with marked obesity (BMI>30) demonstrate a much milder hyperpneic
response to exercise.