EFFECT OF APPLE PEEL EXTRACT ON THE PRODUCTION OF IgG IMMUNOGLOBULINS IN IMMUNOSUPPRESSED MICE

  • Iram Kamal Fatima Jinnah Medical University, Lahore
  • Sehrish Zaffar CMH Medical College Lahore
  • Javaria Arshad Malik CMH Medical College Lahore
  • Maaz Ahmad Rashid Latif Medical College Lahore
Keywords: Immunosuppression, Antibody, Humoral immunity, Apple peel extract

Abstract

Objective: To determine the effect of apple peel extract on serum IgG levels in corticosteroid induced immunosuppression in mice. Methodology: Twenty four Swiss albino mice were divided into four groups, with six animals in each group. Group A was given distilled water. Group B was given prednisolone 4 mg/kg, dissolved in distilled water. Group C and D received prednisolone, followed by 25 mg/kg and 100 mg/kg apple peel extract, respectively, half an hour later. All the doses were given orally as a single morning dose for 14 days. On 15th day, serum IgG levels were measured by mouse ELISA kit. Results: An increase in serum IgG levels was observed in both of the extract-treated groups. However, there was no significant difference between the low dose and high dose extract-treated groups. Conclusions: Apple peel extract has a stimulatory effect on humoral immunity and can be used in adjunct with other drugs in immunocompromised patients. 

Author Biographies

Iram Kamal, Fatima Jinnah Medical University, Lahore
MBBS, Senior Demonstrator, Pharmacology Department, Fatima Jinnah Medical University, Lahore
Sehrish Zaffar, CMH Medical College Lahore
M. Phil Pharmacology, Assistant Professor, Department of Pharmacology, CMH Medical College Lahore
Javaria Arshad Malik, CMH Medical College Lahore
M. Phil Pharmacology, Associate Professor, Pharmacology Department, CMH Medical College Lahore
Maaz Ahmad, Rashid Latif Medical College Lahore
FCPS Community Medicine, Professor & HOD, Department Of Community Medicine, Rashid Latif Medical College Lahore
Published
2019-11-06
Section
Original Article