EFFICACY OF COMBINED INTRALESIONAL MEGLUMINE ANTIMONIATE AND CRYOTHERAPY VERSUS CRYOTHERAPY ALONE FOR THE TREATMENT OF CUTANEOUS LEISHMANIASIS
Keywords: Cryotherapy, Meglumine antimoniate, Leishmaniasis
AbstractObjective: To compare the efficacy of combined intra-lesional meglumine an- timoniate and cryotherapy versus cryotherapy alone for the treatment of cuta- neous leishmaniasis in our population. Methodology: A total of 76 patients were randomly divided into two equal groups A and B. Patients in group A were given combined intra-lesional meglu- mine antimoniate and cryotherapy weekly for 06 weeks and patients in group B were given cryotherapy alone weekly for 06 weeks. At the end of 06 weeks of the treatment, direct skin smear test for Leishmania donovani bodies was performed to determine intervention efficacy. Results: Male to female ratio in A and B groups was 2.4:1. Average age was 29.16 ±10.636 years and 24.39 ±12.262 years respectively. In group A, an effica- cy of 100% was noted in all patients while in group B, an efficacy of 18.4% was noted and no response was observed in 81.6% patients. The efficacy as a whole was statistically significant with p value =0.000. Conclusion: Combined intra-lesional meglumine antimoniate and cryotherapy is a better option for the treatment of cutaneous leishmaniasis as compared to cryotherapy alone.