THE EFFECT OF MODERATE EXERCISE ON VASCULAR EN- DOTHELIAL GROWTH FACTOR EXPRESSION DURING TOOTH SOCKET WOUND HEALING AFTER TOOTH EXTRACTION
Keywords: Moderate exercise, Vascular endothelial growth factor, Wound healing, Wistar rats
AbstractObjective: To determine vascular endothelial growth factor (VEGF) expression during the tooth socket wound healing process post-extraction after moderate exercise. Methodology: Wistar Rats (Rattus norvegicus) were divided into control group (group I) and treatment group (group II). The group II was given moderate exercise with 50% maximal work capacity of time, every day, for 2 weeks. The VEGF expression was observed in macrophages 3 days after tooth extraction and analyzed using immunohistochemistry. Statistical analysis was conducted using an independent t-test. Results: The treatment group had a higher expression of mean VEGF as com- pared to the control group (194.43 +17.213 vs. 131.29 +21.085, respectively). The difference in test results of VEGF expressions was significant, with a p value of =0.000. Conclusion: Moderate exercise increased the expression of VEGF during the tooth socket wound healing process after tooth extraction.