THE EFFECT OF MODERATE EXERCISE ON VASCULAR EN- DOTHELIAL GROWTH FACTOR EXPRESSION DURING TOOTH SOCKET WOUND HEALING AFTER TOOTH EXTRACTION

  • Anis Irmawati Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Farris Zakki Giffari Faculty of Dental Medicine, Universitas Airlangga
  • Aqsa Sjuhada Oki Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Keywords: Moderate exercise, Vascular endothelial growth factor, Wound healing, Wistar rats

Abstract

Objective: To determine vascular endothelial growth factor (VEGF) expression during the tooth socket wound healing process post-extraction after moderate exercise. Methodology: Wistar Rats (Rattus norvegicus) were divided into control group (group I) and treatment group (group II). The group II was given moderate exercise with 50% maximal work capacity of time, every day, for 2 weeks. The VEGF expression was observed in macrophages 3 days after tooth extraction and analyzed using immunohistochemistry. Statistical analysis was conducted using an independent t-test. Results: The treatment group had a higher expression of mean VEGF as com- pared to the control group (194.43 +17.213 vs. 131.29 +21.085, respectively). The difference in test results of VEGF expressions was significant, with a p value of =0.000. Conclusion: Moderate exercise increased the expression of VEGF during the tooth socket wound healing process after tooth extraction.  

Author Biographies

Anis Irmawati, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Associate Professor, Departement of Oral Biology.Departement of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Farris Zakki Giffari, Faculty of Dental Medicine, Universitas Airlangga
Undergraduate Student
Aqsa Sjuhada Oki, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Departement of Oral Biology.
Published
2018-03-23
Section
Original Article